R 59-022 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

R 59-022 (DKGI-I) hydrochloride 是一种 DGK 抑制剂 (IC50: 2.8 μM)。R 59-022 hydrochloride 抑制 OAG 磷酸化为 OAPA。R 59-022 hydrochloride 是一种 5-HT Receptor 拮抗剂，可激活蛋白激酶 C (PKC)。R 59-022 增强血小板中凝血酶诱导的甘油二酯的产生，并抑制嗜中性粒细胞中磷脂酸的产生。

R 59-022 (DKGI-I) hydrochloride is a DGK inhibitor (IC50: 2.8 μM). R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA. R 59-022 hydrochloride is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 hydrochloride potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils.

Western Blot Analysis Cell Line:HeLa cells Concentration:40 uM Incubation Time:30 min Result:Increased the phosphorylation of PKC downstream targets by about 2.5-fold.

Animal Model:SCID mice implanted with U87 GBM cells Dosage:10 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Increased median survival and decreased tumor volume.

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Angiogenesis

PKC

PKC | 5-HT Receptor

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93076-98-3

496.04

C27H27ClFN3OS

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 25 mg/mL (50.40 mM; 超声助溶 )

Cl.O=C1C(=C(N=C2SC=CN21)C)CCN3CCC(=C(C=4C=CC=CC4)C5=CC=C(F)C=C5)CC3

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(-20℃)

With Ice Pack

≥ 2 years